Common variants at 6q22 and 17q21 are associated with intracranial volume
Identifieur interne : 005D82 ( Main/Exploration ); précédent : 005D81; suivant : 005D83Common variants at 6q22 and 17q21 are associated with intracranial volume
Auteurs : M. Arfan Ikram [Pays-Bas] ; Myriam Fornage [États-Unis] ; Albert V. Smith [Islande] ; Sudha Seshadri [États-Unis] ; Reinhold Schmidt [Autriche] ; Stephanie Debette [États-Unis, France] ; Henri A. Vrooman [Pays-Bas] ; Sigurdur Sigurdsson [Islande] ; Stefan Ropele [Autriche] ; H. Rob Taal [Pays-Bas] ; Dennis O. Mook-Kanamori [Pays-Bas, Qatar] ; Laura H. Coker [États-Unis] ; W. T. Jr Longstreth [États-Unis] ; Wiro J. Niessen [Pays-Bas] ; Anita L. Destefano [États-Unis] ; Alexa Beiser [États-Unis] ; Alex P. Zijdenbos [Canada] ; Maksim Struchalin [Pays-Bas] ; Clifford R. Jr Jack [États-Unis] ; Fernando Rivadeneira [Pays-Bas] ; Andre G. Uitterlinden [Pays-Bas] ; David S. Knopman [États-Unis] ; Anna-Liisa Hartikainen [Finlande] ; Craig E. Pennell [Australie] ; Elisabeth Thiering ; Eric A. P. Steegers ; Hakon Hakonarson ; Joachim Heinrich [Australie] ; Lyle J. Palmer ; Marjo-Riitta Jarvelin ; Mark I. Mccarthy ; Struan F. A. Grant ; Beate St Pourcain ; Nicholas J. Timpson ; George Davey Smith ; Ulla Sovio ; Mike A. Nalls ; Rhoda Au [États-Unis, Autriche] ; Albert Hofman [Pays-Bas] ; Haukur Gudnason [Islande] ; Aad Van Der Lugt [Pays-Bas] ; Tamara B. Harris ; William M. Meeks ; Meike W. Vernooij [Pays-Bas] ; Mark A. Van Buchem ; Diane Catellier ; Vincent W. V. Jaddoe [Pays-Bas] ; Vilmundur Gudnason ; B. Gwen Windham ; Philip A. Wolf [États-Unis] ; Cornelia M. Van Duijn [Pays-Bas] ; Thomas H. Jr Mosley ; Helena Schmidt ; Lenore J. Launer ; Monique M. B. Breteler [Pays-Bas] ; Charles DecarliSource :
- Nature genetics [ 1061-4036 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Abstract During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 ========Atilde;- 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 ========Atilde;- 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 ========Atilde;- 10(-12)), localized to the inversion on chromosome 17q21.We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 ========Atilde;- 10(-3) for 6q22 and 1.2 ========Atilde;- 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.
Affiliations:
- Australie, Autriche, Canada, Finlande, France, Islande, Pays-Bas, Qatar, États-Unis
- Caroline du Nord, Hollande-Méridionale, Massachusetts, Minnesota, Texas, Washington (État), Île-de-France
- Leyde, Paris, Rotterdam, Seattle
- Université de Washington
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Arfan Ikram</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Netherlands Consortium for Healthy Aging</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>39 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Institute of Molecular Medicine, University of Texas, Houston Health Sciences Center</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Human Genetics Center, University of Texas, Houston Health Sciences Center</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. 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Rob Taal</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Pediatrics, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>The Generation R Study, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. 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Coker</name><affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Division of Public Health Sciences, Wake Forest School of Medicine</s1><s2>Winston-Salem, North Carolina</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Longstreth, W T Jr" sort="Longstreth, W T Jr" uniqKey="Longstreth W" first="W. T. Jr" last="Longstreth">W. T. Jr Longstreth</name><affiliation wicri:level="4"><inist:fA14 i1="18"><s1>Department of Neurology and Epidemiology, University of Washington</s1><s2>Seattle, Washington</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>7 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Faculty of Applied Sciences, Delft University of Technology</s1><s2>Delft</s2><s3>NLD</s3><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Delft</wicri:noRegion></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. 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Jr" last="Jack">Clifford R. Jr Jack</name><affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Department of Radiology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Internal Medicine, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Internal Medicine, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S." last="Knopman">David S. Knopman</name><affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Department of Neurology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Institute of Clinical Medicine, Department of Obstetrics and Gynecology, University of Oulu</s1><s2>Oulu</s2><s3>FIN</s3><sZ>23 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>School of Women's & Infant's Health, University of Western Australia</s1><s2>Crawley, Western Australia</s2><s3>AUS</s3><sZ>24 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Crawley, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name></author><author><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A. P." last="Steegers">Eric A. P. Steegers</name></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>School of Women's & Infant's Health, University of Western Australia</s1><s2>Crawley, Western Australia</s2><s3>AUS</s3><sZ>24 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Crawley, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name></author><author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F. A." last="Grant">Struan F. A. Grant</name></author><author><name sortKey="St Pourcain, Beate" sort="St Pourcain, Beate" uniqKey="St Pourcain B" first="Beate" last="St Pourcain">Beate St Pourcain</name></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name></author><author><name sortKey="Nalls, Mike A" sort="Nalls, Mike A" uniqKey="Nalls M" first="Mike A." last="Nalls">Mike A. Nalls</name></author><author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>38 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, Medical University Graz</s1><s2>Graz</s2><s3>AUT</s3><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Netherlands Consortium for Healthy Aging</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>39 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Gudnason, Haukur" sort="Gudnason, Haukur" uniqKey="Gudnason H" first="Haukur" last="Gudnason">Haukur Gudnason</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Icelandic Heart Association</s1><s2>Kopavogur</s2><s3>ISL</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Icelandic Heart Association</wicri:noRegion></affiliation></author><author><name sortKey="Der Lugt, Aad Van" sort="Der Lugt, Aad Van" uniqKey="Der Lugt A" first="Aad Van" last="Der Lugt">Aad Van Der Lugt</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name></author><author><name sortKey="Meeks, William M" sort="Meeks, William M" uniqKey="Meeks W" first="William M." last="Meeks">William M. Meeks</name></author><author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Buchem, Mark A Van" sort="Buchem, Mark A Van" uniqKey="Buchem M" first="Mark A. Van" last="Buchem">Mark A. Van Buchem</name></author><author><name sortKey="Catellier, Diane" sort="Catellier, Diane" uniqKey="Catellier D" first="Diane" last="Catellier">Diane Catellier</name></author><author><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W. V." last="Jaddoe">Vincent W. V. Jaddoe</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Pediatrics, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>The Generation R Study, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name></author><author><name sortKey="Windham, B Gwen" sort="Windham, B Gwen" uniqKey="Windham B" first="B. Gwen" last="Windham">B. Gwen Windham</name></author><author><name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>38 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>The National Heart, Lung, and Blood Institute's Framingham Heart Study</s1><s2>Framingham, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Duijn, Cornelia M Van" sort="Duijn, Cornelia M Van" uniqKey="Duijn C" first="Cornelia M. Van" last="Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Netherlands Consortium for Healthy Aging</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>39 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Mosley, Thomas H Jr" sort="Mosley, Thomas H Jr" uniqKey="Mosley T" first="Thomas H. Jr" last="Mosley">Thomas H. Jr Mosley</name></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name></author><author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Netherlands Consortium for Healthy Aging</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>39 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0224087</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0224087 INIST</idno><idno type="RBID">Pascal:12-0224087</idno><idno type="wicri:Area/PascalFrancis/Corpus">001367</idno><idno type="wicri:Area/PascalFrancis/Curation">004B47</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001264</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001264</idno><idno type="wicri:doubleKey">1061-4036:2012:Arfan Ikram M:common:variants:at</idno><idno type="wicri:Area/Main/Merge">006099</idno><idno type="wicri:Area/Main/Curation">005D82</idno><idno type="wicri:Area/Main/Exploration">005D82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Common variants at 6q22 and 17q21 are associated with intracranial volume</title><author><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Netherlands Consortium for Healthy Aging</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>39 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Institute of Molecular Medicine, University of Texas, Houston Health Sciences Center</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Human Genetics Center, University of Texas, Houston Health Sciences Center</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Icelandic Heart Association</s1><s2>Kopavogur</s2><s3>ISL</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Icelandic Heart Association</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Faculty of Medicine, University of Iceland</s1><s2>Reykjavik</s2><s3>ISL</s3><sZ>3 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>38 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>The National Heart, Lung, and Blood Institute's Framingham Heart Study</s1><s2>Framingham, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, Medical University Graz</s1><s2>Graz</s2><s3>AUT</s3><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>38 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vrooman, Henri A" sort="Vrooman, Henri A" uniqKey="Vrooman H" first="Henri A." last="Vrooman">Henri A. Vrooman</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>7 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Icelandic Heart Association</s1><s2>Kopavogur</s2><s3>ISL</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Icelandic Heart Association</wicri:noRegion></affiliation></author><author><name sortKey="Ropele, Stefan" sort="Ropele, Stefan" uniqKey="Ropele S" first="Stefan" last="Ropele">Stefan Ropele</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, Medical University Graz</s1><s2>Graz</s2><s3>AUT</s3><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Taal, H Rob" sort="Taal, H Rob" uniqKey="Taal H" first="H. Rob" last="Taal">H. Rob Taal</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Pediatrics, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>The Generation R Study, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Pediatrics, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>The Generation R Study, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Physiology and Biophysics, Weill Cornell Medical College-Qatar</s1><s2>Doha</s2><s3>QAT</s3><sZ>11 aut.</sZ></inist:fA14><country>Qatar</country><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name><affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Division of Public Health Sciences, Wake Forest School of Medicine</s1><s2>Winston-Salem, North Carolina</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Longstreth, W T Jr" sort="Longstreth, W T Jr" uniqKey="Longstreth W" first="W. T. Jr" last="Longstreth">W. T. Jr Longstreth</name><affiliation wicri:level="4"><inist:fA14 i1="18"><s1>Department of Neurology and Epidemiology, University of Washington</s1><s2>Seattle, Washington</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>7 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Faculty of Applied Sciences, Delft University of Technology</s1><s2>Delft</s2><s3>NLD</s3><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Delft</wicri:noRegion></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>38 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>The National Heart, Lung, and Blood Institute's Framingham Heart Study</s1><s2>Framingham, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>38 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>The National Heart, Lung, and Blood Institute's Framingham Heart Study</s1><s2>Framingham, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Zijdenbos, Alex P" sort="Zijdenbos, Alex P" uniqKey="Zijdenbos A" first="Alex P." last="Zijdenbos">Alex P. Zijdenbos</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Biospective Inc</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Biospective Inc</wicri:noRegion></affiliation></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name><affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Department of Radiology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Internal Medicine, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Internal Medicine, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S." last="Knopman">David S. Knopman</name><affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Department of Neurology, Mayo Clinic</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Institute of Clinical Medicine, Department of Obstetrics and Gynecology, University of Oulu</s1><s2>Oulu</s2><s3>FIN</s3><sZ>23 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>School of Women's & Infant's Health, University of Western Australia</s1><s2>Crawley, Western Australia</s2><s3>AUS</s3><sZ>24 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Crawley, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name></author><author><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A. P." last="Steegers">Eric A. P. Steegers</name></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>School of Women's & Infant's Health, University of Western Australia</s1><s2>Crawley, Western Australia</s2><s3>AUS</s3><sZ>24 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Crawley, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name></author><author><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F. A." last="Grant">Struan F. A. Grant</name></author><author><name sortKey="St Pourcain, Beate" sort="St Pourcain, Beate" uniqKey="St Pourcain B" first="Beate" last="St Pourcain">Beate St Pourcain</name></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name></author><author><name sortKey="Nalls, Mike A" sort="Nalls, Mike A" uniqKey="Nalls M" first="Mike A." last="Nalls">Mike A. Nalls</name></author><author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>38 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, Medical University Graz</s1><s2>Graz</s2><s3>AUT</s3><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Netherlands Consortium for Healthy Aging</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>39 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Gudnason, Haukur" sort="Gudnason, Haukur" uniqKey="Gudnason H" first="Haukur" last="Gudnason">Haukur Gudnason</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Icelandic Heart Association</s1><s2>Kopavogur</s2><s3>ISL</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Icelandic Heart Association</wicri:noRegion></affiliation></author><author><name sortKey="Der Lugt, Aad Van" sort="Der Lugt, Aad Van" uniqKey="Der Lugt A" first="Aad Van" last="Der Lugt">Aad Van Der Lugt</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name></author><author><name sortKey="Meeks, William M" sort="Meeks, William M" uniqKey="Meeks W" first="William M." last="Meeks">William M. Meeks</name></author><author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>41 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Buchem, Mark A Van" sort="Buchem, Mark A Van" uniqKey="Buchem M" first="Mark A. Van" last="Buchem">Mark A. Van Buchem</name></author><author><name sortKey="Catellier, Diane" sort="Catellier, Diane" uniqKey="Catellier D" first="Diane" last="Catellier">Diane Catellier</name></author><author><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W. V." last="Jaddoe">Vincent W. V. Jaddoe</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Pediatrics, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>The Generation R Study, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name></author><author><name sortKey="Windham, B Gwen" sort="Windham, B Gwen" uniqKey="Windham B" first="B. Gwen" last="Windham">B. Gwen Windham</name></author><author><name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>38 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>The National Heart, Lung, and Blood Institute's Framingham Heart Study</s1><s2>Framingham, Massachusetts</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Duijn, Cornelia M Van" sort="Duijn, Cornelia M Van" uniqKey="Duijn C" first="Cornelia M. Van" last="Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Netherlands Consortium for Healthy Aging</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>39 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Mosley, Thomas H Jr" sort="Mosley, Thomas H Jr" uniqKey="Mosley T" first="Thomas H. Jr" last="Mosley">Thomas H. Jr Mosley</name></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name></author><author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>39 aut.</sZ><sZ>44 aut.</sZ><sZ>47 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Netherlands Consortium for Healthy Aging</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>39 aut.</sZ><sZ>51 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name></author></analytic><series><title level="j" type="main">Nature genetics</title><title level="j" type="abbreviated">Nat. genet.</title><idno type="ISSN">1061-4036</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Nature genetics</title><title level="j" type="abbreviated">Nat. genet.</title><idno type="ISSN">1061-4036</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Genetic mapping</term><term>Intracranial</term><term>Variant</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Variant</term><term>Carte génétique</term><term>Intracrânien</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 ========Atilde;- 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 ========Atilde;- 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 ========Atilde;- 10(-12)), localized to the inversion on chromosome 17q21.We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 ========Atilde;- 10(-3) for 6q22 and 1.2 ========Atilde;- 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>Canada</li><li>Finlande</li><li>France</li><li>Islande</li><li>Pays-Bas</li><li>Qatar</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Hollande-Méridionale</li><li>Massachusetts</li><li>Minnesota</li><li>Texas</li><li>Washington (État)</li><li>Île-de-France</li></region><settlement><li>Leyde</li><li>Paris</li><li>Rotterdam</li><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><noCountry><name sortKey="Buchem, Mark A Van" sort="Buchem, Mark A Van" uniqKey="Buchem M" first="Mark A. Van" last="Buchem">Mark A. Van Buchem</name><name sortKey="Catellier, Diane" sort="Catellier, Diane" uniqKey="Catellier D" first="Diane" last="Catellier">Diane Catellier</name><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name><name sortKey="Grant, Struan F A" sort="Grant, Struan F A" uniqKey="Grant S" first="Struan F. A." last="Grant">Struan F. A. Grant</name><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name><name sortKey="Meeks, William M" sort="Meeks, William M" uniqKey="Meeks W" first="William M." last="Meeks">William M. Meeks</name><name sortKey="Mosley, Thomas H Jr" sort="Mosley, Thomas H Jr" uniqKey="Mosley T" first="Thomas H. Jr" last="Mosley">Thomas H. Jr Mosley</name><name sortKey="Nalls, Mike A" sort="Nalls, Mike A" uniqKey="Nalls M" first="Mike A." last="Nalls">Mike A. Nalls</name><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><name sortKey="St Pourcain, Beate" sort="St Pourcain, Beate" uniqKey="St Pourcain B" first="Beate" last="St Pourcain">Beate St Pourcain</name><name sortKey="Steegers, Eric A P" sort="Steegers, Eric A P" uniqKey="Steegers E" first="Eric A. P." last="Steegers">Eric A. P. Steegers</name><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name><name sortKey="Windham, B Gwen" sort="Windham, B Gwen" uniqKey="Windham B" first="B. Gwen" last="Windham">B. Gwen Windham</name></noCountry><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name></region><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name><name sortKey="Der Lugt, Aad Van" sort="Der Lugt, Aad Van" uniqKey="Der Lugt A" first="Aad Van" last="Der Lugt">Aad Van Der Lugt</name><name sortKey="Duijn, Cornelia M Van" sort="Duijn, Cornelia M Van" uniqKey="Duijn C" first="Cornelia M. Van" last="Duijn">Cornelia M. Van Duijn</name><name sortKey="Duijn, Cornelia M Van" sort="Duijn, Cornelia M Van" uniqKey="Duijn C" first="Cornelia M. Van" last="Duijn">Cornelia M. Van Duijn</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W. V." last="Jaddoe">Vincent W. V. Jaddoe</name><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W. V." last="Jaddoe">Vincent W. V. Jaddoe</name><name sortKey="Jaddoe, Vincent W V" sort="Jaddoe, Vincent W V" uniqKey="Jaddoe V" first="Vincent W. V." last="Jaddoe">Vincent W. V. Jaddoe</name><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><name sortKey="Taal, H Rob" sort="Taal, H Rob" uniqKey="Taal H" first="H. Rob" last="Taal">H. Rob Taal</name><name sortKey="Taal, H Rob" sort="Taal, H Rob" uniqKey="Taal H" first="H. Rob" last="Taal">H. Rob Taal</name><name sortKey="Taal, H Rob" sort="Taal, H Rob" uniqKey="Taal H" first="H. Rob" last="Taal">H. Rob Taal</name><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name><name sortKey="Vrooman, Henri A" sort="Vrooman, Henri A" uniqKey="Vrooman H" first="Henri A." last="Vrooman">Henri A. Vrooman</name><name sortKey="Vrooman, Henri A" sort="Vrooman, Henri A" uniqKey="Vrooman H" first="Henri A." last="Vrooman">Henri A. Vrooman</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name></region><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S." last="Knopman">David S. Knopman</name><name sortKey="Longstreth, W T Jr" sort="Longstreth, W T Jr" uniqKey="Longstreth W" first="W. T. Jr" last="Longstreth">W. T. Jr Longstreth</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name><name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name></country><country name="Islande"><noRegion><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name></noRegion><name sortKey="Gudnason, Haukur" sort="Gudnason, Haukur" uniqKey="Gudnason H" first="Haukur" last="Gudnason">Haukur Gudnason</name><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name></country><country name="Autriche"><noRegion><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name></noRegion><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><name sortKey="Ropele, Stefan" sort="Ropele, Stefan" uniqKey="Ropele S" first="Stefan" last="Ropele">Stefan Ropele</name></country><country name="France"><region name="Île-de-France"><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name></region></country><country name="Qatar"><noRegion><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Zijdenbos, Alex P" sort="Zijdenbos, Alex P" uniqKey="Zijdenbos A" first="Alex P." last="Zijdenbos">Alex P. Zijdenbos</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name></noRegion><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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